97．胃仙-U
出处：按学科分类—医药、卫生 军事医学科学出版社《临床常用进口药物手册》第541页（7222字）
【中文释文】：
双层药片，具有双重效能的胃肠专用药
〔概述〕
由于都市生活紧张，患胃肠病者，正有与日俱增之势。故世界各国皆有推出新胃药，但均不理想。医药界在积极研究过程中，更深切明了胃溃疡及十二指肠溃疡的主因，实由缺乏某种营养素所致。数年来本厂根据此项理论，进行研究，结果决定以维生素U(抗溃疡素)最为理想，立即采用为“胃仙-U”之主剂。此宝贵维生素U早在1955年已由美国斯坦福大学医学院曾理教授提出报告时，谓在新鲜青菜中，皆含有若干成分。此种要素对胃溃疡及十二指肠溃疡、胃酸过多，确具功效。既能保持消化管粘液正常状态，并能防止胃酸侵蚀胃壁，使不致引起胃溃疡及十二指肠溃疡，更可预防复发。
“胃仙-U”双层药片所含维生素U曾经日本庆应大学医学院内科系、金泽大学医学院内科系、热海胃及十二指肠医院、东京大学医科分院外科系、京都府立医科大学第三内科学院等着名医学机构，广泛临床实验，提出报告，证实效果优良。世界各国医药权威，均加好评，广泛采用，以预防及治疗胃溃疡、十二指肠溃疡、胃酸过多等症。
“胃仙-U”双层药片味甜芬芳所含维生素U为主剂外，另配合其他数种重要胃肠制酸剂，而使互相发挥作用，以收更大效能。此“胃仙-U”双层药片证明治疗胃溃疡及十二指肠溃病病人，成绩甚佳，得各方面好评。本厂对此实验，极为满意，立即大量生产，专供预防及治疗胃溃疡、十二指肠溃疡、胃酸过多等症。
1．主要成分及性质 维生素U原质，乃白色结晶粉末，药味稍浓，易致潮湿，且易溶解。
2．片剂构造 胃仙-U胃肠专药，其药片的结构，与其他药片制法完全不同，药片之内，另有药片，成为新型双层药片。
胃仙-U双层药片服后，其外层迅速溶解，稍后内层亦逐渐溶化，因此藉内外层溶解之调节，将效能分为2段，使更能发挥双重药力。
3．优点 胃仙-U双层药片，其外层含有强力制酸剂，服后迅速溶解即将过多胃酸中和。保护胃膜，此时内层药片主制剂的维生素U立即开始发挥效能，深入溃疡部分，治疗患处。
此双层药片构成为内外两层，将制酸剂与其维生素U分离，使其主剂维生素U不致因接触胃酸而减少其效果，故能保持耐久药力，得以发挥最大功效。此乃本品之优点。
胃仙-U双层药片外层呈浅绿色，气味芬芳，每片均印有U字样，以资鉴别，其综合处方如下：内层药片(奶白色)
维生素U25mg，淀粉酶60mg
外层药片(浅绿色)干燥氢氧化铝160mg、三硅酸镁145mg、甘草酸钠、葡糖醛酸、薄荷脑、叶绿素，牛胆浸膏。
根据最近医药报告，胃仙-U主剂维生素U与甘草酸及克雨科伦酸并用，对肝脏消毒，具有优良效果，因此医药界对胃仙-U双层药片能预防与治疗肝病一事，亦非常重视，甚为乐意采用。
4．效能 胃仙-U能以最少药量而收最大效能，避免施用手术麻烦，更可缩短治疗时间，减轻病人痛苦。
(1)胃仙-U治疗胃溃疡与十二指肠溃疡、胃炎，服后且可预防复发。
(2)胃仙-U调节胃肠功能，节制胃液过度分泌，中和胃酸及消除胃痛。
(3)胃仙-U解除胃肠饱滞，胃胀，使胃肠功能正常，得以吸收食物中之营养素，保持胃肠健康。
(4)胃仙-U强化肝脏功能，加强血液循环及新陈代谢作用而促进身体健康。
〔适应证〕
胃溃疡、十二指肠溃疡、胃炎、胃酸过多、消化不良、胃痛、肝病、强化肝脏功能，更可解毒。
〔用法及用量〕
服用需视病人病状轻重而定，普通标准如下：
1．普通胃肠不适 每日服3次每次1片(每隔4h1次)，于餐后服用，应继续服用10d，以收痊愈之效。
2．中和胃酸过多，及预防胃溃疡与十二指肠溃疡 每日服3次，每次1～2片(每隔4h1次)，于餐后服用，直至病症消失时再继续服用2～3周则可预防胃溃疡症及十二指肠溃疡症复发。
3．治疗初期胃溃疡症及十二指肠溃疡症 发现初期胃溃疡症及十二指肠溃疡症时，宜连续服用4～5周，每次服2片，3次／d，于餐后服用。
4．儿童用量 应按照年龄而减少用量(10～15岁减半，6～10岁1／3，4～6岁1／4)。
5．孕妇 医师指导下亦可服用，安全无忌。
6．中年人 酒精过量，以致胃肠不适，如服一片，可助消化，使胃部舒畅。
〔注意事项〕
1．在治疗开始时，宜小心饮食，但数日后，即可进食如常(切要正常)。
2．为求迅速痊愈，在服药期间，饮食方面，尤须注意，切勿食脂质、大豆类及一切刺激性食物，并尽量减少吸烟与饮酒。
3．服用后，须将瓶盖扭紧，以防潮湿。
〔安全可靠〕
胃仙-U双层药片性温和，不寒不燥，且至今未发现有副作用，故长期按照剂量服用，保证绝对安全。
〔胃仙-U双层药片包装〕
每瓶30片及100片。
〔生产厂家〕
日本滋贺县制药有限公司
【外文释文】：
A Significant Advance in the Treatment of Gastcic and Duodenal Ulcers．
Facts about gastric and duodenal ulcers
In our modern life，more and more people are suffering from gastric and duodenal ulcers．This condition is caused by an excess of hydrochloric acid in the gastric juice，brought about by irregular eating habits and the nervous tension due to the stress of daily life．
A wonderful discovery
Recent research has led to the discovery of a remarkable new substance，first extracted from cabbages，which has an extraordinary healing effect on gastric and duodenal ulcers．
This substance，now called methylmethionine sulfonium chloride is the active ingredient which we proudly present in our Weisen-U．
Chemistry
This substance，the main ingredient in Weisen-U，has successfully undergone extensive trials in leading Japanese hospitals and institutes of learning such as：
*Keio University Medical School，Physical Section．
*Kanazawa University Medical School，Physical Section．
*Atami Stomach and Duodenal Hospital．
*Surgical Service of Tokyo University Hospital．
*Third Internal Service of Kyoto Prefectural Medical School Hospital．
This substance was also studied in California，and astounding relieyes were reported in the Stanford Medical Bulletin(May 1955；204)．
Weisen-U the successor of Weisen
The well-known Weisen，a gastric and duodenal ulcer remedy，has been marketed for over ten years and thousands of satisfied users can testify to its effectiveness；but as progress marches on，a new and more modern remedy Weisen-U，has been introduced．
Weisen-U is free from side effects and is absolutely safe for everybody including pregnant women，even when taken over long periods．
Improved composition of dual action Weisen-U tablets
Each Weisen-U tablet consists of 2 tablets an outer green tablet containing antacids andan enclosed inner core tablet containing methylmethionine sulfonium chloride．
Outer tablet(green)
Dried Aluminum Hydroxide Gel 160．0 mg
Magnesium Trisilicate 145．0 mg
also contains Sodium Glycyrrhizinate，Glucuronic acid，Ext．Bile Bovini，1-Menthol and Chlorophyll．
Diagram of the structure of dual-action Weisen-U Tablet
Inner tablet(white to slightly yellowish)
Methylmethionine Sulfonium Chloride 25．0 mg
Diastase Serong 12．0 mg
(JP．Diastase equilibrates 60．0 mg)
After administration，the outer green tablet dissolves，releasing antacids which immediately neutralize the excess acid present as well as protect the stomach，and then，the inner tablet dissolves，releasing the anti-ulcer agent which calms the vagus nerve，and so prevents more acid from being produced．
Weisen-U is thus a wonder drug with a double action：the outer tablet gives instant relief and the inner tablet provides lasting effect．
Effectiveness of Weisen-U
Weisen-U has the following properties：
1．It relieves the discomfort and pain of gastric and duodenal ulcer．
2．It aids healing of the ulcer and prevents relapses．
3．It relieves heart-burn，gastritis，stomach pain，belching and over-acidity．
Dosage
The usual adult dose is one or two tablets to be taken three times a day after meals．This dose may be adjusted according to the age of the patient and severity of the complaint．To prevent a relapse，treatment should be continued two or three weeks after the symptoms have disappeared．
The discomfort felt after over-eating or a sumptuous dinner is quickly relieved by a dose of Weisen-U．
Recommendation
Ulcer healing will be accelerated if patients，at the commencement of treatment，take a soft diet and avoid alcohol，spices and indigestible food：after 2 or 3 weeks，a normal but bland diet may be resumed．
Packlng
Weisen-U dual-action tablets are packed in bottles of 30 and 100．
Manufacturer
Shigaken Pharm．Ind．Co．，Ltd．Japan